STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - CHARACTERIZATION OF DISRUPTIVE DELETIONS IN THE ALPHA-AMMONIUM GROUP BINDING-SITE OF TYROSYL-TRANSFER RNA-SYNTHETASE

被引：27

作者：

LOWE, DM

WINTER, G

FERSHT, AR

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 19期

关键词：

D O I：

10.1021/bi00393a014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：6038 / 6043

页数：6

共 13 条

[1]

BLOW DM, 1985, BIOL MACROMOL, V2, P442

[2] CRYSTAL-STRUCTURE OF A DELETION MUTANT OF A TYROSYL-TRANSFER RNA-SYNTHETASE COMPLEXED WITH TYROSINE [J].

BRICK, P ;

BLOW, DM .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 194 (02) :287-297

[3] PURIFICATION AND PHYSICAL CHARACTERIZATION OF TYROSYL RIBONUCLEIC ACID SYNTHETASES FROM ESCHERICHIA COLI AND BACILLUS SUBTILIS [J].

CALENDAR, R ;

BERG, P .

BIOCHEMISTRY, 1966, 5 (05) :1681-&

[4]

FERSHT A, 1985, ENZYME STRUCTURE MEC, pCH12

[5] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].

FERSHT, AR ;

SHI, JP ;

KNILLJONES, J ;

LOWE, DM ;

WILKINSON, AJ ;

BLOW, DM ;

BRICK, P ;

CARTER, P ;

WAYE, MMY ;

WINTER, G .

NATURE, 1985, 314 (6008) :235-238

[6] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS [J].

FERSHT, AR ;

LEATHERBARROW, RJ ;

WELLS, TNC .

BIOCHEMISTRY, 1987, 26 (19) :6030-6038

[7] PROBING HISTIDINE SUBSTRATE INTERACTIONS IN TYROSYL-TRANSFER RNA-SYNTHETASE USING ASPARAGINE AND GLUTAMINE REPLACEMENTS [J].

LOWE, DM ;

FERSHT, AR ;

WILKINSON, AJ ;

CARTER, P ;

WINTER, G .

BIOCHEMISTRY, 1985, 24 (19) :5106-5109

[8]

PENEFSKY HS, 1977, J BIOL CHEM, V252, P2891

[9] DELETION MUTAGENESIS USING AN M13 SPLINT - THE N-TERMINAL STRUCTURAL DOMAIN OF TYROSYL-TRANSFER RNA-SYNTHETASE (B-STEAROTHERMOPHILUS) CATALYZES THE FORMATION OF TYROSYL ADENYLATE [J].

WAYE, MMY ;

WINTER, G ;

WILKINSON, AJ ;

FERSHT, AR .

EMBO JOURNAL, 1983, 2 (10) :1827-1829

[10] USE OF BINDING-ENERGY IN CATALYSIS ANALYZED BY MUTAGENESIS OF THE TYROSYL-TRANSFER RNA-SYNTHETASE [J].

WELLS, TNC ;

FERSHT, AR .

BIOCHEMISTRY, 1986, 25 (08) :1881-1886

← 1 2 →