PROBING HISTIDINE SUBSTRATE INTERACTIONS IN TYROSYL-TRANSFER RNA-SYNTHETASE USING ASPARAGINE AND GLUTAMINE REPLACEMENTS

被引：93

作者：

LOWE, DM

FERSHT, AR

WILKINSON, AJ

CARTER, P

WINTER, G

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] MRC,MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

BIOCHEMISTRY | 1985年 / 24卷 / 19期

关键词：

D O I：

10.1021/bi00340a022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：5106 / 5109

页数：4

共 12 条

[1] CONSERVED CYSTEINE AND HISTIDINE-RESIDUES IN THE STRUCTURES OF THE TYROSYL AND METHIONYL-TRANSFER RNA-SYNTHETASES
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[2] PURIFICATION AND PHYSICAL CHARACTERIZATION OF TYROSYL RIBONUCLEIC ACID SYNTHETASES FROM ESCHERICHIA COLI AND BACILLUS SUBTILIS
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[3] THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS)
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[4] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING
FERSHT, AR
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WILKINSON, AJ
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BRICK, P
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[5] DEMONSTRATION OF 2 REACTION PATHWAYS FOR AMINOACYLATION OF TRANSFER-RNA - APPLICATION OF PULSED QUENCHED FLOW TECHNIQUE
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[J]. BIOCHEMISTRY, 1975, 14 (15) : 3350 - 3356
[6] LIGAND-BINDING AND ENZYMIC CATALYSIS COUPLED THROUGH SUBUNITS IN TYROSYL-TRANSFER-RNA SYNTHETASE
FERSHT, AR
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KOCH, GLE
[J]. BIOCHEMISTRY, 1975, 14 (01) : 13 - 18
[7] ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING
FERSHT, AR
SHI, JP
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WAYE, MMY
WINTER, GP
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07): : 467 - 473
[8] TYROSYL-TRANSFER-RNA SYNTHETASE FROM ESCHERICHIA-COLI - STOICHIOMETRY OF LIGAND-BINDING AND HALF-OF-SITES REACTIVITY IN AMINOACYLATION
JAKES, R
FERSHT, AR
[J]. BIOCHEMISTRY, 1975, 14 (15) : 3344 - 3350
[9] AMINO-ACID ACTIVATION IN CRYSTALLINE TYROSYL-TRANSFER RNA-SYNTHETASE FROM BACILLUS-STEAROTHERMOPHILUS
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[J]. JOURNAL OF MOLECULAR BIOLOGY, 1981, 145 (03) : 489 - 500
[10] SITE-DIRECTED MUTAGENESIS AS A PROBE OF ENZYME STRUCTURE AND CATALYSIS - TYROSYL-TRANSFER RNA-SYNTHETASE CYSTEINE-35 TO GLYCINE-35 MUTATION
WILKINSON, AJ
FERSHT, AR
BLOW, DM
WINTER, G
[J]. BIOCHEMISTRY, 1983, 22 (15) : 3581 - 3586

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