COMPLEMENT FACTOR-II DEFICIENCY - A CLINICAL AND SEROLOGICAL FAMILY STUDY

被引：11

作者：

DCRUZ, D ^{[1
]}

TAYLOR, J ^{[1
]}

AHMED, T ^{[1
]}

ASHERSON, R ^{[1
]}

KHAMASHTA, M ^{[1
]}

HUGHES, GRV ^{[1
]}

机构：

[1] ST THOMAS HOSP,RAYNE INST,LUPUS ARTHRITIS RES UNIT,LONDON SE1 7EH,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 11期

关键词：

D O I：

10.1136/ard.51.11.1254

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inherited complement deficiencies are associated with a variety of connective tissue diseases. A family with inherited deficiency of complement factor 2 (C2) is described in which two family members with homozygous C2 deficiency developed cutaneous vasculitis and sicca syndrome. The other family members had heterozygous C2 deficiency and each member had the HLA-A25, B18, DR2 (w15) haplotype. The mother had seropositive rheumatoid arthritis. Further studies showed the presence of cryoglobulins, antibodies against endothelial cells, and anticardiolipin antibodies.

引用

页码：1254 / 1256

页数：3

共 11 条

[1]

AGNELLO V, 1978, MEDICINE, V57, P1

[2] COMPLEMENT-HUMAN HISTOCOMPATIBILITY ANTIGEN HAPLOTYPES IN C2 DEFICIENCY [J].

AWDEH, ZL ;

RAUM, DD ;

GLASS, D ;

AGNELLO, V ;

SCHUR, PH ;

JOHNSTON, RB ;

GELFAND, EW ;

BALLOW, M ;

YUNIS, E ;

ALPER, CA .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (02) :581-583

[3] ANTIENDOTHELIAL CELL ANTIBODIES IN PATIENTS WITH THE ANTIPHOSPHOLIPID SYNDROME [J].

CERVERA, R ;

KHAMASHTA, MA ;

FONT, J ;

RAMIREZ, G ;

DCRUZ, D ;

MONTALBAN, J ;

LOPEZSOTO, A ;

ASHERSON, RA ;

INGELMO, M ;

HUGHES, GRV .

AUTOIMMUNITY, 1991, 11 (01) :1-6

[4] THE MOLECULAR-BASIS FOR GENETIC DEFICIENCY OF THE 2ND COMPONENT OF HUMAN-COMPLEMENT [J].

COLE, FS ;

WHITEHEAD, AS ;

AUERBACH, HS ;

LINT, T ;

ZEITZ, HJ ;

KILBRIDGE, P ;

COLTEN, HR .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (01) :11-16

[5]

DCRUZ DP, 1991, CLIN EXP IMMUNOL, V85, P254

[6] INHERITED DEFICIENCY OF 2ND COMPONENT OF COMPLEMENT - RHEUMATIC DISEASE ASSOCIATIONS [J].

GLASS, D ;

RAUM, D ;

GIBSON, D ;

STILLMAN, JS ;

SCHUR, PH .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (04) :853-861

[7]

HEURKENS AHM, 1989, CLIN EXP IMMUNOL, V78, P7

[8] SEROLOGIC STUDIES IN A FAMILY WITH HETEROZYGOUS C2 DEFICIENCY [J].

MCCARTY, DJ ;

TAN, EM ;

ZVAIFLER, NJ ;

KOETHE, S ;

DUQUESNOY, RJ .

AMERICAN JOURNAL OF MEDICINE, 1981, 71 (06) :945-948

[9] CRYOGLOBULINEMIA - A CLINICAL AND LABORATORY STUDY .2. CRYOGLOBULINS WITH RHEUMATOID FACTOR ACTIVITY [J].

MELTZER, M ;

FRANKLIN, EC ;

ELIAS, K ;

MCCLUSKEY, RT ;

COOPER, N .

AMERICAN JOURNAL OF MEDICINE, 1966, 40 (06) :837-+

[10]

PARISER KM, 1978, J IMMUNOL, V121, P2580

← 1 2 →