FORMATION OF AN AMINO REDUCTION PRODUCT OF METRONIDAZOLE IN BACTERIAL CULTURES - LACK OF BACTERICIDAL ACTIVITY

被引:20
作者
EHLHARDT, WJ
BEAULIEU, BB
GOLDMAN, P
机构
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,665 HUNTINGTON AVE,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115
关键词
D O I
10.1016/0006-2952(87)90698-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:259 / 264
页数:6
相关论文
共 20 条
[1]   ELECTRON-AFFINIC SENSITIZATION .7. CORRELATION BETWEEN STRUCTURES ONE-ELECTRON REDUCTION POTENTIALS, AND EFFICIENCIES OF NITROIMIDAZOLES AS HYPOXIC CELL RADIOSENSITIZERS [J].
ADAMS, GE ;
FLOCKHART, IR ;
SMITHEN, CE ;
STRATFORD, IJ ;
WARDMAN, P ;
WATTS, ME .
RADIATION RESEARCH, 1976, 67 (01) :9-20
[2]   RELATIONSHIP BETWEEN METRONIDAZOLE METABOLISM AND BACTERICIDAL ACTIVITY [J].
CHRYSTAL, EJT ;
KOCH, RL ;
MCLAFFERTY, MA ;
GOLDMAN, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (04) :566-573
[3]  
CHRYSTAL EJT, 1980, MOL PHARMACOL, V18, P105
[4]  
COSAR C, 1966, ARZNEI-FORSCHUNG, V16, P23
[5]   PHARMACOKINETIC AND METABOLIC STUDIES OF HYPOXIC CELL RADIOSENSITIZER MISONIDAZOLE [J].
FLOCKHART, IR ;
LARGE, P ;
TROUP, D ;
MALCOLM, SL ;
MARTEN, TR .
XENOBIOTICA, 1978, 8 (02) :97-105
[6]   COMPARING THE REDUCTION OF NITROIMIDAZOLES IN BACTERIA AND MAMMALIAN-TISSUES AND RELATING IT TO BIOLOGICAL-ACTIVITY [J].
GOLDMAN, P ;
KOCH, RL ;
YEUNG, TC ;
CHRYSTAL, EJT ;
BEAULIEU, BB ;
MCLAFFERTY, MA ;
SUDLOW, G .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :43-51
[7]   COMPARATIVE MISONIDAZOLE METABOLISM IN ANAEROBIC-BACTERIA AND HYPOXIC CHINESE-HAMSTER LUNG FIBROBLAST (V-79-473) CELLS [J].
KOCH, RL ;
ROSE, C ;
RICH, TA ;
GOLDMAN, P .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (03) :411-414
[8]   ROLE OF THE INTESTINAL FLORA IN THE METABOLISM OF MISONIDAZOLE [J].
KOCH, RL ;
BEAULIEU, BB ;
GOLDMAN, P .
BIOCHEMICAL PHARMACOLOGY, 1980, 29 (24) :3281-3284
[9]  
KOCH RL, 1979, J PHARMACOL EXP THER, V208, P406
[10]   ACETAMIDE - METABOLITE OF METRONIDAZOLE FORMED BY THE INTESTINAL FLORA [J].
KOCH, RL ;
CHRYSTAL, EJT ;
BEAULIEU, BB ;
GOLDMAN, P .
BIOCHEMICAL PHARMACOLOGY, 1979, 28 (24) :3611-3615