THE HUMAN COLLAGENASE-3 (CLG3) GENE IS LOCATED ON CHROMOSOME 11Q22.3 CLUSTERED TO OTHER MEMBERS OF THE MATRIX METALLOPROTEINASE GENE FAMILY

被引：51

作者：

PENDAS, AM

MATILLA, T

ESTIVILL, X

LOPEZOTIN, C

机构：

[1] UNIV OVIEDO,DEPT BIOL FUNC,E-33006 OVIEDO,SPAIN

[2] HOSP DURAN & REYNALS,IRO,DEPT MOLEC GENET,BARCELONA,SPAIN

来源：

GENOMICS | 1995年 / 26卷 / 03期

关键词：

D O I：

10.1016/0888-7543(95)80186-P

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The gene coding for human collagenase-3 (CLG3), a recently described matrix metalloproteinase produced by breast carcinomas, has been localized by fluorescence in situ hybridization on chromosome 11q22.3. Physical mapping of an isolated YAC clone containing CLG3 has revealed that this gene is tightly linked to those encoding other matrix metalloproteinases, including fibroblast collagenase (CLG1), stromelysin-1 (STMY1), and stromelysin-2 (STMY2). Further mapping of this region using pulsed-field gel electrophoresis has shown that the CLG3 gene is localized to the telomeric side of the matrix metalloproteinase cluster, the relative order of the loci centromere-STMY2-CLG1-STMY1-CLG3-telomere. (C) 1995 Academic Press, Inc.

引用

页码：615 / 618

页数：4

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