HIP-70 - A PROTEIN-INDUCED BY ESTROGEN IN THE BRAIN AND LH-RH IN THE PITUITARY

被引：44

作者：

MOBBS, CV ^{[1
]}

FINK, G ^{[1
]}

PFAFF, DW ^{[1
]}

机构：

[1] UNIV EDINBURGH,DEPT PHARMACOL,MRC,BRAIN METAB UNIT,EDINBURGH EH8 9JZ,MIDLOTHIAN,SCOTLAND

来源：

SCIENCE | 1990年 / 247卷 / 4949期

关键词：

D O I：

10.1126/science.2181662

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Estrogen and luteinizing hormone-releasing hormone (LH-RH) interact to influence both behavior and gonadotropin release. However, little is known about the biochemical mechanisms that mediate the effects of these hormones or their interactions. The most prominent protein induced by estrogen in the ventromedial hypothalamus has the same amino-terminal sequence as the most prominent protein induced by LH-RH in the pituitary in vitro and in vivo; these proteins comigrate on two-dimensional gels. Furthermore, the hormonal induction may be caused by modification of a constitutive protein with the same molecular weight (70,000) but a slightly more acidic isoelectric point, whose level is inversely related to the level of the induced form after estrogen treatment. Thus estrogen and LH-RH may interact by additively or synergistically inducing this protein, which is called HIP-70.

引用

页码：1477 / 1479

页数：3

共 19 条

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