ENZYMES IN THE SYNTHESIS OF CHIRAL DRUGS

被引：242

作者：

MARGOLIN, AL

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, OH

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 1993年 / 15卷 / 04期

关键词：

CHIRAL DRUGS; BIOCATALYSIS; KINETIC RESOLUTION; ENZYMES IN SYNTHESIS;

D O I：

10.1016/0141-0229(93)90149-V

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The majority of synthetic chiral drugs are now marketed as racemates. This situation is rapidly changing due to the recent advances in asymmetric chemical synthesis and biocatalytic methods. This article reviews the use of enzymes in the synthesis and modification of optically pure drugs. Special attention is focused on the synthesis of new pharmaceuticals which may require efficient procedures for large-scale synthesis in the future.

引用

页码：266 / 280

页数：15

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