2-FLUORO-2-PHENYLPROPANOIC ACID - PREPARATION AND USE AS CHIRAL DERIVATION AGENT

被引：17

作者：

HAMMAN, S

机构：

[1] Laboratoire de Cinétique et Dynamique Moléculaire, Université Joseph Fourier, UFR de Chimie, 38041 Grenoble Cedex

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1993年 / 60卷 / 2-3期

关键词：

D O I：

10.1016/S0022-1139(00)80036-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantiomers of 2-fluoro-2-phenyl propanoic acid have been separated and their absolute configurations determined: the specific rotation of the acid with an R configuration is [alpha]20D, =-28.5-degrees (c=1.5, ethanol). This acid has been used as a chiral derivatizing agent. Esters and amides prepared from this acid and chiral alcohols or amines present important fluorine chemical shift differences between the diastereoisomers.

引用

页码：225 / 232

页数：8

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