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THE NEUROPROTECTIVE ACTIONS OF KYNURENIC ACID AND MK-801 IN GERBILS ARE SYNERGISTIC AND NOT RELATED TO HYPOTHERMIA
被引:91
作者
:
GILL, R
论文数:
0
引用数:
0
h-index:
0
机构:
MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND
MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND
GILL, R
[
1
]
WOODRUFF, GN
论文数:
0
引用数:
0
h-index:
0
机构:
MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND
MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND
WOODRUFF, GN
[
1
]
机构
:
[1]
MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND
来源
:
EUROPEAN JOURNAL OF PHARMACOLOGY
|
1990年
/ 176卷
/ 02期
关键词
:
Ischaemia;
Kynurenic acid;
MK-801;
Neuroprotection;
D O I
:
10.1016/0014-2999(90)90522-8
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
The broad spectrum excitatory amino acid antagonist, kynurenic acid was evaluated in a transient forebrain ischaemia model in gerbils. When administered i.p., 15 min prior to a 5 minperiod of ischaemia, a dose-related neuroprotective effect was seen with 800 mg/kg of kynurenic acid showing very good protection. A combination of kynurenic acid (200 or 400 mg/kg) and MK-801 (0.1 mg/kg) gave a synergistic neuroprotective effect. Neither kynurenic acid (200 or 400 mg/kg) nor MK-801 (0.3 mg/kg) was neuroprotective when administered by itself 30 min post-ischaemically, but when co-administered significant protection of the CA1 pyramidal neurones of the hippocampus was seen. In addition, we examined the effect of maintaining core body temperature on the neuroprotective action of MK-801 and kynurenic acid following the suggestion that it was a hypothermic effect of MK-801 which resulted in neuroprotection in gerbils. When the body temperature of the gerbils was maintained at 37°C for a period of 24 h it did not affect the neuroprotective action of MK-801 (0.1 or 10 mg/kg) or kynurenic acid (200 mg/kg). © 1990.
引用
收藏
页码:143 / 149
页数:7
相关论文
共 32 条
[31]
Watson G.B., 1988, NEUROSCI RES COMMUN, V2, P169
[32]
THE ANTICONVULSANT MK-801 IS A POTENT N-METHYL-D-ASPARTATE ANTAGONIST
WONG, EHF
论文数:
0
引用数:
0
h-index:
0
WONG, EHF
KEMP, JA
论文数:
0
引用数:
0
h-index:
0
KEMP, JA
PRIESTLEY, T
论文数:
0
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0
h-index:
0
PRIESTLEY, T
KNIGHT, AR
论文数:
0
引用数:
0
h-index:
0
KNIGHT, AR
WOODRUFF, GN
论文数:
0
引用数:
0
h-index:
0
WOODRUFF, GN
IVERSEN, LL
论文数:
0
引用数:
0
h-index:
0
IVERSEN, LL
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1986,
83
(18)
: 7104
-
7108
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共 32 条
[31]
Watson G.B., 1988, NEUROSCI RES COMMUN, V2, P169
[32]
THE ANTICONVULSANT MK-801 IS A POTENT N-METHYL-D-ASPARTATE ANTAGONIST
WONG, EHF
论文数:
0
引用数:
0
h-index:
0
WONG, EHF
KEMP, JA
论文数:
0
引用数:
0
h-index:
0
KEMP, JA
PRIESTLEY, T
论文数:
0
引用数:
0
h-index:
0
PRIESTLEY, T
KNIGHT, AR
论文数:
0
引用数:
0
h-index:
0
KNIGHT, AR
WOODRUFF, GN
论文数:
0
引用数:
0
h-index:
0
WOODRUFF, GN
IVERSEN, LL
论文数:
0
引用数:
0
h-index:
0
IVERSEN, LL
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1986,
83
(18)
: 7104
-
7108
←
1
2
3
4
→