CLASSIFICATION OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY BY B-CELL SECRETION OF IGM AND IGG IN RESPONSE TO ANTI-IGM AND INTERLEUKIN-2

被引：156

作者：

BRYANT, A

CALVER, NC

TOUBI, E

WEBSTER, ADB

FARRANT, J

机构：

[1] Immunodeficiency Disease Research Group, Clinical Research Centre, Harrow, HA1 3UJ, Watford Road

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1990年 / 56卷 / 02期

关键词：

D O I：

10.1016/0090-1229(90)90145-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have classified patients with common variable immunodeficiency (CVI) on the basis of the ability of their B cells to respond to anti-IgM and interleukin (IL)-2 in vitro. Group A had cells unable to secrete IgM or IgG, Group B secreted IgM alone, and Group C secreted both IgM and IgG. A separate small group of patients lacked peripheral B cells. Where Ig secretion was present with anti-IgM and IL-2, EBV increased it, but where it was absent, EBV only induced IgM secretion in two out of eight Group A patients and IgG in one out of five Group B patients. These classifications are related to the sex of the patient and may represent different loci of the block in B-cell differentiation in CVI. © 1990.

引用

页码：239 / 248

页数：10