DYNAMIC KINETIC RESOLUTION OF CYCLIC BETA-KETOESTERS WITH PREFORMED OR PREPARED IN-SITU CHIRAL DIPHOSPHINE-RUTHENIUM(II) CATALYSTS

被引：53

作者：

GENET, JP ^{[1
]}

PFISTER, X ^{[1
]}

RATOVELOMANANAVIDAL, V ^{[1
]}

PINEL, C ^{[1
]}

LAFFITTE, JA ^{[1
]}

机构：

[1] ELF AQUITAINE CO,GRP RECH LACQ,DEPT CHIM FINE & BIOCONVERS,F-64170 ARTIX,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期

关键词：

ASYMMETRIC HYDROGENATION; CHIRAL RUTHENIUM CATALYSTS; BETA-HYDROXY ESTERS;

D O I：

10.1016/S0040-4039(00)60727-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reduction of racemic beta-keto esters having the tetralone structure by chiral ruthenium(II) catalysts is realized with an ideal kinetic dynamic resolution. Remarkably, high anti selectivity approaching 100% and enantioselectivity (up to 97%) using atropisomeric ligands are obtained. The trans beta-hydroxy esters thus available are useful starting materials for production of enantiomerically pure compounds.

引用

页码：4559 / 4562

页数：4

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