EFFECTS OF ACUTE AND CHRONIC PREDNISOLONE TREATMENT ON SERUM ZINC LEVELS IN RATS WITH ADJUVANT ARTHRITIS

被引:11
作者
FONTAINE, J
NEVE, J
PERETZ, A
CAPEL, P
FAMAEY, JP
机构
[1] UNIV HOSP ST PIERRE,DEPT RHEUMATOL & PHYS MED,BRUSSELS,BELGIUM
[2] UNIV LIBRE BRUXELLES,INST PHARM,MED CHEM LAB,B-1050 BRUSSELS,BELGIUM
[3] UNIV HOSP ST PIERRE,HEMATOL LAB,BRUSSELS,BELGIUM
来源
AGENTS AND ACTIONS | 1991年 / 33卷 / 3-4期
关键词
D O I
10.1007/BF01986570
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Several studies in animals and humans have independently demonstrated that zinc metabolism is significantly affected either by inflammation or by glucocorticoid administration. The relative importance of these two factors was assessed in this study by the investigation of the effects on serum zinc concentrations of acute and chronic prednisolone treatments in adjuvant arthritis rats and in healthy controls animals. Acute steroid administration (3 mg/kg, i.p.) caused a rapid drop in serum zinc followed by a quick recovery, regardless to the fact that these concentrations were normal (healthy animals) or already reduced by the inflammatory process. However, the modification occurred faster in inflamed animals. Chronic steroid administration (0.58 to 0.78 mg/kg/day during 1 to 4 weeks) had a more complex effect. A previous experiment in healthy rats demonstrated that such a treatment only induced a slight decrease in serum zinc. In adjuvant arthritis animals, the early steroid treatment of the induced process promoted a further decrease in serum zinc level while a delayed treatment did not result in additional changes.
引用
收藏
页码:247 / 253
页数:7
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