IMMUNOHISTOCHEMICAL LOCALIZATION OF HEPATOCYTE GROWTH-FACTOR PROTEIN IN PANCREAS ISLET A-CELLS OF MAN AND RATS

被引：31

作者：

TSUDA, H

IWASE, T

MATSUMOTO, K

ITO, M

HIRONO, I

NISHIDA, Y

YAMAMOTO, M

TATEMATSU, M

MATSUMOTO, K

NAKAMURA, T

机构：

[1] FUJITA HLTH UNIV,SCH MED,DEPT PEDIAT SURG,TOYOAKE,AICHI 47011,JAPAN

[2] AICHI CANC CTR,RES INST,ULTRASTRUCT RES LAB,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

[3] KYUSHU UNIV,FAC SCI,DEPT BIOL,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1992年 / 83卷 / 12期

关键词：

HEPATOCYTE GROWTH FACTOR; PANCREAS ISLET A-CELL; IMMUNOHISTOCHEMISTRY;

D O I：

10.1111/j.1349-7006.1992.tb02756.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocyte growth factor (HGF), a potent mitogen for adult rat hepatocytes in primary culture, has previously been shown to be primarily expressed in the nonparenchymal cells of the liver. Using polyclonal antisera against human and rat HGFs we studied the tissue distribution of HGF immunohistochemically and found the most intense staining in the pancreas islet cells in both man (autopsy cases) and the rat. Differential localization of 4 pancreas islet hormones, glucagon, insulin, somatostatin and pancreatic polypeptide, revealed HGF to be preferentially expressed within the glucagon-positive cells. The results indicate that HGF is primarily produced or stored in A-cells and may act as a growth factor in a paracrine and an endocrine fashion, like various other hormones.

引用

收藏

页码：1262 / 1266

页数：5

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