RELATIONSHIP BETWEEN THE HYDROPHOBIC AND HYDROPHILIC MOLECULAR-PARAMETERS OF SOME MONOAMINE-OXIDASE INHIBITORY DRUGS, DETERMINED BY MEANS OF ADSORPTIVE AND REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY

被引：26

作者：

CSERHATI, T ^{[1
]}

MAGYAR, K ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,DEPT PHARMACOL,H-1085 BUDAPEST 8,HUNGARY

来源：

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS | 1992年 / 24卷 / 3-4期

关键词：

MONOAMINE OXIDASE INHIBITOR; ADSORPTION CAPACITY; LIPOPHILICITY;

D O I：

10.1016/0165-022X(94)90077-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The absorption capacity, the specific hydrophilic surface area, the lipophilicity and the specific hydrophobic surface area of 17 monoamine oxidase inhibitory drugs were determined by means of adsorptive and reversed-phase thin-layer chromatography for future application of these molecular parameters in quantitative structure-activity relationship studies. Principal component analysis suggests that most of the physicochemical parameters have a different information content, and their application in the elucidation of their mode of action is therefore justified.

引用

页码：249 / 264

页数：16

共 36 条

[1] STUDY OF THE LIPOPHILIC CHARACTER OF XANTHINE AND ADENOSINE DERIVATIVES .2. RELATIONSHIPS BETWEEN LOG-K', LOG-RM AND LOG-P VALUES [J].

BIAGI, GL ;

GUERRA, MC ;

BARBARO, AM ;

BARBIERI, S ;

RECANATINI, M ;

BOREA, PA .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1990, 13 (05) :913-927

[2]

BLANEY F, 1990, CHEM IND, V3, P791

[3] PHYSICOCHEMICAL ASPECTS OF PHLOEM TRANSLOCATION OF HERBICIDES [J].

BROMILOW, RH ;

CHAMBERLAIN, K ;

EVANS, AA .

WEED SCIENCE, 1990, 38 (03) :305-314

[4]

BUDAVARIBARANY Z, 1990, J LIQ CHROMATOGR, V13, P1485

[5] AMINOPYRAZOLONES - NOVEL PHOTOSYSTEM-II INHIBITORS [J].

CAMILLERI, P ;

ASTLES, DP ;

KERR, MW ;

SPENCER, JE .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1990, 38 (07) :1601-1603

[6] MOBILITY OF VARIOUS BUFFERS IN REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY [J].

CSERHATI, T ;

GASPARIC, J .

JOURNAL OF CHROMATOGRAPHY, 1987, 394 (02) :368-374

[7] REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY USED TO STUDY THE SIMULTANEOUS EFFECT OF PH AND ION STRENGTH ON THE LIPOPHILICITY OF CHLORHEXIDINE [J].

CSERHATI, T ;

SZOGYI, M ;

LELKES, L .

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1988, 16 (04) :263-270

[8] LIPOPHILICITY DETERMINATION OF SOME FULLY PROTECTED PEPTIDES AND AMINO-ACIDS [J].

CSERHATI, T ;

BORDAS, B ;

OSAPAY, G .

CHROMATOGRAPHIA, 1987, 23 (03) :184-188

[9] THIN-LAYER CHROMATOGRAPHY OF SOME METHYLATED AMINO-ACIDS WITH AQUEOUS SALT-SOLUTIONS USED AS ELUENTS [J].

CSERHATI, T ;

BORDAS, B ;

TYIHAK, E .

JOURNAL OF CHROMATOGRAPHY, 1986, 365 :289-296

[10] DETERMINATION OF THE LIPOPHILICITY OF SOME ANILINE DERIVATIVES BY REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY - THE EFFECT OF THE ORGANIC-PHASE IN THE ELUENT [J].

CSERHATI, T .

CHROMATOGRAPHIA, 1984, 18 (06) :318-322

← 1 2 3 4 →