STUDY OF THE LIPOPHILIC CHARACTER OF XANTHINE AND ADENOSINE DERIVATIVES .2. RELATIONSHIPS BETWEEN LOG-K', LOG-RM AND LOG-P VALUES

The log k’ values of a series of xanthine and adenosine derivatives were measured by means of a reversed-phase HPLC. The HPLC data were shown to be well correlated with previously reported RH and RMC18 values. The equations describing the relationships log k/rm and log k'/RHC18 allowed the calculation of the log k’ values of some compounds, which were not tested in the HPLC system. Since the relationship log k'/log P is very close to the previously described relationships RH /log P and RHC18/log P one can\conclude that reversed-phase TLC and HPLC are very similar in describing the lipophilicity of the compounds. © 1990, Taylor & Francis Group, LLC. All rights reserved.