EFFECTS OF LEG MUSCLE PUMPING AND TENSING ON ORTHOSTATIC ARTERIAL-PRESSURE - A STUDY IN NORMAL SUBJECTS AND PATIENTS WITH AUTONOMIC FAILURE

被引:87
作者
TENHARKEL, ADJ [1 ]
VANLIESHOUT, JJ [1 ]
WIELING, W [1 ]
机构
[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT MED,1105 AZ AMSTERDAM,NETHERLANDS
关键词
AUTONOMIC FAILURE; CARDIAC OUTPUT; CENTRAL BLOOD VOLUME; HEART RATE; ORTHOSTATIC HYPOTENSION; STROKE VOLUME; SYSTEMIC VASCULAR RESISTANCE; VENOUS POOLING;
D O I
10.1042/cs0870553
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1. The effects of leg muscle pumping (tiptoeing) and tensing (leg-crossing) on orthostatic blood pressure were investigated in six healthy adult subjects (aged 28-34 years) and in seven patients with severe hypo-adrenergic orthostatic hypotension (aged 20-65 years). 2. Finger arterial pressure was monitored. Relative changes in left ventricular stroke volume were computed by a pulse contour method. 3. Tiptoeing increased mean arterial pressure (7 +/- 5 mmHg) in the healthy subjects, but not in the patients, whereas cardiac output increased in both groups, although by more in the healthy adults than in the patients (35 +/- 10% versus 20 +/- 11%, P < 0.05). Systemic vascular resistance decreased substantially in both groups while tiptoeing. Leg-crossing did not affect arterial pressure in the healthy subjects, although stroke volume had increased. In contrast, in the patients an increase in cardiac output (16 +/- 12%) and mean blood pressure (13 +/- 13 mmHg) was observed. 4. Tiptoeing and leg-crossing have different effects on orthostatic blood pressure in healthy adult subjects and in patients with autonomic failure. In normal humans, tiptoeing increases arterial pressure, whereas leg-crossing has little effect. In the patients, in contrast, tiptoeing has little effect, whereas leg-crossing increases arterial pressure considerably. Patients with autonomic failure should be instructed to apply leg-crossing to combat orthostatic dizziness.
引用
收藏
页码:553 / 558
页数:6
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