REDUCTION OF BRAIN PHOSPHOCREATINE IN BIPOLAR-II DISORDER DETECTED BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY

被引：161

作者：

KATO, T ^{[1
]}

TAKAHASHI, S ^{[1
]}

SHIOIRI, T ^{[1
]}

MURASHITA, J ^{[1
]}

HAMAKAWA, H ^{[1
]}

INUBUSHI, T ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI, DEPT PSYCHIAT, MOLEC NEUROBIOL RES CTR, OTSU, SHIGA 52021, JAPAN

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1994年 / 31卷 / 02期

关键词：

BIPOLAR AFFECTIVE DISORDER; P-31 MAGNETIC RESONANCE SPECTROSCOPY; CREATINE PHOSPHATE;

D O I：

10.1016/0165-0327(94)90116-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain phosphorus metabolism was measured by P-31-MRS in 15 patients with bipolar II disorder (BP II) and 14 patients with bipolar I disorder (BP I). Phosphocreatine (PCr)levels were significantly lower in patients with BP II in all three psychiatric states compared to 59 normal controls (PCr (%) was 13.5 +/- 1.5 (mean +/- SD) for controls, and 12.2 +/- 1.7, 12.1 +/- 1.3, 12.0 +/- 1.9 for hypomanic, euthymic and depressed bipolar II patients respectively). High values of phosphomonoester (PME) were found in BP II patients in the hypomanic and depressive states, but PME values in the euthymic state did not differ significantly from controls. Intracellular pH of BP II patients in all three psychiatric phases was similar to control values, whereas euthymic BP I patients had lower pH values. These results suggest that brain high energy phosphate metabolism may be impaired in BP II and that there may be pathophysiological differences between BP I and BP II.

引用

页码：125 / 133

页数：9