EFFECT OF BASIC FIBROBLAST GROWTH-FACTOR ON REINNERVATION OF GASTRIC MICROVESSELS - POSSIBLE RELEVANCE TO ULCER RECURRENCE

被引:18
作者
NAKAMURA, M
ODA, M
INOUE, J
ITO, T
AKIBA, Y
KITAJIMA, M
TSUCHIYA, M
ISHII, H
机构
[1] KEIO UNIV,SCH MED,DEPT INTERNAL MED,SHINJUKU KU,TOKYO 160,JAPAN
[2] KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU,TOKYO 160,JAPAN
关键词
BASIC FIBROBLAST GROWTH FACTOR; REINNERVATION; STOMACH; ACETIC ACID-INDUCED GASTRIC ULCER; CGRP; VIP;
D O I
10.1007/BF02285191
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Basic fibroblast growth factor (bFGF) has well-established angiogenic and ulcer healing actions. bFGF has also been found to induce neural regeneration in the central nervous system. Thus, the present study was undertaken to clarify the effect of basic fibroblast growth factor on the regeneration of autonomic nerves in the granulation tissues following the induction of experimental gastric ulcer induced by acetic acid in rats. Rats were divided into control, acetic acid alone, and acetic acid plus acid-stable human recombinant basic fibroblast growth factor (CS23, 1 mu g/100 g body wt., every 12 hr for three days, or one or two weeks, through oral gastric intubation) groups. As a result, few autonomic nerves were recognized surrounding the newly formed arterioles and venules in the acetic acid alone group. In the CS23-treated group, the cholinergic, calcitonin gene-related peptide and vasoactive intestinal peptide-immunoreactive nerves were clearly recognized near the microvessels, but few adrenergic nerves were seen even after CS23 treatment. From these observations, basic fibroblast growth factor was suggested to promote the reinnervation of the newly formed microvessels.
引用
收藏
页码:1451 / 1458
页数:8
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