学术探索
学术期刊
新闻热点
数据分析
智能评审

MOLECULAR CONTROL OF LIFE AND DEATH

被引：87
作者：
YUAN, JY [1 ]
机构：
[1] HARVARD UNIV,SCH MED,BOSTON,MA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 02期
关键词：
D O I：
10.1016/0955-0674(95)80030-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent evidence has shown that two of the three key genes in the programmed cell death pathway of Caenorhabditis elegans, ced-9 (a cell death suppressor) and ced-3 (a cell death inducer), encode proteins that share structural and functional similarities with the mammalian proto-oncogene product Bcl-2 and interleukin-1 beta converting enzyme, respectively. These findings reveal key molecules that control lire and death decisions in vertebrates.
引用
收藏
页码：211 / 214
页数：4
相关论文
共 35 条
  • [1] CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18
    BAKHSHI, A
    JENSEN, JP
    GOLDMAN, P
    WRIGHT, JJ
    MCBRIDE, OW
    EPSTEIN, AL
    KORSMEYER, SJ
    [J]. CELL, 1985, 41 (03) : 899 - 906
  • [2] BCL-X, A BCL-2-RELATED GENE THAT FUNCTIONS AS A DOMINANT REGULATOR OF APOPTOTIC CELL-DEATH
    BOISE, LH
    GONZALEZGARCIA, M
    POSTEMA, CE
    DING, LY
    LINDSTEN, T
    TURKA, LA
    MAO, XH
    NUNEZ, G
    THOMPSON, CB
    [J]. CELL, 1993, 74 (04) : 597 - 608
  • [3] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME
    CERRETTI, DP
    KOZLOSKY, CJ
    MOSLEY, B
    NELSON, N
    VANNESS, K
    GREENSTREET, TA
    MARCH, CJ
    KRONHEIM, SR
    DRUCK, T
    CANNIZZARO, LA
    HUEBNER, K
    BLACK, RA
    [J]. SCIENCE, 1992, 256 (5053) : 97 - 100
  • [4] CLONING AND STRUCTURAL-ANALYSIS OF CDNAS FOR BCL-2 AND A HYBRID BCL-2/IMMUNOGLOBULIN TRANSCRIPT RESULTING FROM THE T(14-18) TRANSLOCATION
    CLEARY, ML
    SMITH, SD
    SKLAR, J
    [J]. CELL, 1986, 47 (01) : 19 - 28
  • [5] DIGIOVINE FS, 1990, IMMUNOL TODAY, V11, P13
  • [6] DINARELLO CA, 1991, BLOOD, V77, P1627
  • [7] GENETIC-CONTROL OF PROGRAMMED CELL-DEATH IN THE NEMATODE C-ELEGANS
    ELLIS, HM
    HORVITZ, HR
    [J]. CELL, 1986, 44 (06) : 817 - 829
  • [8] MECHANISMS AND FUNCTIONS OF CELL-DEATH
    ELLIS, RE
    YUAN, JY
    HORVITZ, HR
    [J]. ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 : 663 - 698
  • [9] FERNANDESALNEMR.T, 1994, J BIOL CHEM, V269, P30761
  • [10] PREVENTION OF VERTEBRATE NEURONAL DEATH BY THE CRMA GENE
    GAGLIARDINI, V
    FERNANDEZ, PA
    LEE, RKK
    DREXLER, HCA
    ROTELLO, RJ
    FISHMAN, MC
    YUAN, J
    [J]. SCIENCE, 1994, 263 (5148) : 826 - 828
1234