LOOSELY COUPLED MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION INDUCED BY PROTOPORPHYRIN

被引：22

作者：

STUMPF, DA

MCCABE, ERB

PARKS, JK

BULLEN, WW

SCHIFF, S

机构：

[1] Pediatric Neurology, University of Colorado Medical Center, Denver, CO 80262

来源：

BIOCHEMICAL MEDICINE | 1979年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-2944(79)90070-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enzymatic blocks may produce crises by secondarily altering mitochondrial respiration. © 1979.

引用

页码：182 / 189

页数：8

共 33 条

[11]

Estabrook R.W., 1967, METHODS ENZYMOL, V10, P41, DOI [10.1016/0076-6879(67)10010-4, DOI 10.1016/0076-6879(67)10010-4]

[12]

GREER M, 1976, HDB CLIN NEUROLOGY, V27, P429

[13] INHIBITION BY METHYLMALONIC ACID OF MALATE TRANSPORT BY DICARBOXYLATE CARRIER IN RAT LIVER MITOCHONDRIA - POSSIBLE EXPLANATION FOR HYPOGLYCEMIA IN METHYLMALONIC ACIDURIA [J].