A COMMON DENOMINATOR LINKING GLYCOGEN-METABOLISM, NUCLEAR ONCOGENES AND DEVELOPMENT

被引：152

作者：

WOODGETT, JR

机构：

[1] J.R. Woodgett is at the Ludwig Institute for Cancer Research, London, W1P 8BT

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 05期

关键词：

D O I：

10.1016/0968-0004(91)90071-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A ubiquitous protein-serine kinase, initially implicated in glycogen regulation, has surfaced unexpectedly in the fields of nuclear oncogenes and fruitfly development. This unusual linkage may reflect the role of this kinase in phosphorylating proteins normally activated by dephosphorylation, thus providing a priming function. Loss of such a primer would result in constitutive activation of substrates, a scenario concordant with the dramatic and pleiotropic phenotype observed in Drosophila null mutants.

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页码：177 / 181

页数：5

相关论文

共 27 条

[1] REDOX REGULATION OF FOS AND JUN DNA-BINDING ACTIVITY INVITRO [J].

ABATE, C ;

PATEL, L ;

RAUSCHER, FJ ;

CURRAN, T .

SCIENCE, 1990, 249 (4973) :1157-1161

[2] CONTROL OF C-JUN ACTIVITY BY INTERACTION OF A CELL-SPECIFIC INHIBITOR WITH REGULATORY DOMAIN-DELTA - DIFFERENCES BETWEEN V-JUN AND C-JUN [J].

BAICHWAL, VR ;

TJIAN, R .

CELL, 1990, 63 (04) :815-825

[3] EFFICIENT TRANSFORMATION OF CHICKEN-EMBRYO FIBROBLASTS BY C-JUN REQUIRES STRUCTURAL MODIFICATION IN CODING AND NONCODING SEQUENCES [J].

BOS, TJ ;

MONTECLARO, FS ;

MITSUNOBU, F ;

BALL, AR ;

CHANG, CHW ;

NISHIMURA, T ;

VOGT, PK .

GENES & DEVELOPMENT, 1990, 4 (10) :1677-1687

[4] AN EARLY EMBRYONIC PRODUCT OF THE GENE SHAGGY ENCODES A SERINE THREONINE PROTEIN-KINASE RELATED TO THE CDC28/CDC2+ SUBFAMILY [J].

BOUROUIS, M ;

MOORE, P ;

RUEL, L ;

GRAU, Y ;

HEITZLER, P ;

SIMPSON, P .

EMBO JOURNAL, 1990, 9 (09) :2877-2884

[5] ACTIVATION OF PROTEIN-KINASE-C DECREASES PHOSPHORYLATION OF C-JUN AT SITES THAT NEGATIVELY REGULATE ITS DNA-BINDING ACTIVITY [J].

BOYLE, WJ ;

SMEAL, T ;

DEFIZE, LHK ;

ANGEL, P ;

WOODGETT, JR ;

KARIN, M ;

HUNTER, T .

CELL, 1991, 64 (03) :573-584

[6] DIMERS, LEUCINE ZIPPERS AND DNA-BINDING DOMAINS [J].

BUSCH, SJ ;

SASSONECORSI, P .

TRENDS IN GENETICS, 1990, 6 (02) :36-40

[7] MOLECULAR ANALYSIS OF A CELLULAR DECISION DURING EMBRYONIC-DEVELOPMENT OF DROSOPHILA-MELANOGASTER - EPIDERMOGENESIS OR NEUROGENESIS [J].

CAMPOSORTEGA, JA ;

KNUST, E .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 190 (01) :1-10

[8] THE ROLE OF PROTEIN-PHOSPHORYLATION IN THE HORMONAL-CONTROL OF ENZYME-ACTIVITY [J].

COHEN, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 151 (03) :439-448

[9]

COHEN P, 1985, MOL BASIS INSULIN AC, P213

[10] THE MOLECULAR MECHANISM BY WHICH INSULIN STIMUALTES GLYCOGEN-SYNTHESIS IN MAMMALIAN SKELETAL-MUSCLE [J].

DENT, P ;

LAVOINNE, A ;

NAKIELNY, S ;

CAUDWELL, FB ;

WATT, P ;

COHEN, P .

NATURE, 1990, 348 (6299) :302-308