PHYSICAL MAPPING OF THE GENES FOR 3 COMPONENTS OF THE MOUSE DNA-REPLICATION COMPLEX - POLYMERASE ALPHA TO THE X-CHROMOSOME, PRIMASE P49 SUBUNIT TO CHROMOSOME-10, AND PRIMASE P58 SUBUNIT TO CHROMOSOME-1

被引:16
作者
ADLER, DA
TSENG, BY
WANG, TSF
DISTECHE, CM
机构
[1] UNIV WASHINGTON,SCH MED,DEPT PATHOL SM-30,SEATTLE,WA 98195
[2] UNIV CALIF SAN DIEGO,SCH MED,DEPT MED,LA JOLLA,CA 92093
[3] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,EXPTL ONCOL LAB,STANFORD,CA 94305
关键词
D O I
10.1016/0888-7543(91)90357-K
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
DNA polymerase α and primase are two key enzymatic components of the eukaryotic DNA replication complex. In situ hybridization of cloned cDNAs for mouse DNA polymerase α and for the two subunits of mouse primase has been utilized to physically map these genes in the mouse genome. The DNA polymerase α gene (Pola) was mapped to the mouse X chromosome in region C-D. The gene encoding the p58 subunit of primase (Prim2) was located to mouse chromosome 1 in region A5-B and the p49 subunit gene (Prim1) was found to be on mouse chromosome 10 in the distal part of band D that is close to the telomere. Current knowledge of mouse and human conserved chromosomal regions along with the findings presented here lead to predictions of where the genes for the DNA primase subunits may be found in the human genome: the p58 subunit gene may be on human chromosome 2 and the p49 subunit gene on human chromosome 12. The mapping of Pola to region C-D of the mouse X chromosome adds a new marker in a conserved region between the mouse X chromosome and region Xp21-22.1 of the human X chromosome. © 1991.
引用
收藏
页码:642 / 646
页数:5
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