The multifunctional Ca2+/calmodulin-dependent protein kinases

被引:182
作者
Schulman, Howard [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Pharmacol, Stanford, CA 94305 USA
关键词
D O I
10.1016/0955-0674(93)90111-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ca2+ mediates the effect of many hormones, neurotransmitters and growth factors on contractility and motility, carbohydrate metabolism, cell cycle, gene expression and neuronal plasticity. Multifunctional Ca2+/calmodulin-dependent (CaM) kinase, CaM kinase la, CaM kinase Ib and CaM kinase IV are four of the kinases that mediate Ca2+-signaling pathways. Recent studies have clarified our understanding of their structure, regulation and function.
引用
收藏
页码:247 / 253
页数:7
相关论文
共 42 条
  • [11] HANSON PI, 1992, J BIOL CHEM, V267, P17216
  • [12] SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
    IKURA, M
    CLORE, GM
    GRONENBORN, AM
    ZHU, G
    KLEE, CB
    BAX, A
    [J]. SCIENCE, 1992, 256 (5057) : 632 - 638
  • [13] ACQUISITION AND LOSS OF A NEURONAL CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE DURING NEURONAL DIFFERENTIATION
    JENSEN, KF
    OHMSTEDE, CA
    FISHER, RS
    OLIN, JK
    SAHYOUN, N
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 4050 - 4053
  • [14] STRUCTURAL FEATURES OF CA2+ CALMODULIN-DEPENDENT PROTEIN KINASE-II REVEALED BY ELECTRON-MICROSCOPY
    KANASEKI, T
    IKEUCHI, Y
    SUGIURA, H
    YAMAUCHI, T
    [J]. JOURNAL OF CELL BIOLOGY, 1991, 115 (04) : 1049 - 1060
  • [15] STRUCTURE, EXPRESSION, AND CHROMOSOME LOCATION OF THE GENE FOR THE BETA-SUBUNIT OF BRAIN-SPECIFIC CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE-II IDENTIFIED BY TRANSGENE INTEGRATION IN AN EMBRYONIC LETHAL MOUSE MUTANT
    KARLS, U
    MULLER, U
    GILBERT, DJ
    COPELAND, NG
    JENKINS, NA
    HARBERS, K
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (08) : 3644 - 3652
  • [16] CONCERTED REGULATION OF PROTEIN-PHOSPHORYLATION AND DEPHOSPHORYLATION BY CALMODULIN
    KLEE, CB
    [J]. NEUROCHEMICAL RESEARCH, 1991, 16 (09) : 1059 - 1065
  • [17] STIMULUS-INDUCED COORDINATE CHANGES IN MESSENGER-RNA ABUNDANCE IN SINGLE POSTSYNAPTIC HIPPOCAMPAL CA1 NEURONS
    MACKLER, SA
    BROOKS, BP
    EBERWINE, JH
    [J]. NEURON, 1992, 9 (03) : 539 - 548
  • [18] MULTIPLE CA-2+ SIGNALING PATHWAYS CONVERGE ON CAM KINASE IN PC12 CELLS
    MACNICOL, M
    SCHULMAN, H
    [J]. FEBS LETTERS, 1992, 304 (2-3) : 237 - 240
  • [19] MACNICOL M, 1992, J BIOL CHEM, V267, P12197
  • [20] INHIBITION OF POSTSYNAPTIC PKC OR CAMKII BLOCKS INDUCTION BUT NOT EXPRESSION OF LTP
    MALINOW, R
    SCHULMAN, H
    TSIEN, RW
    [J]. SCIENCE, 1989, 245 (4920) : 862 - 866