HEPATITIS-B VIRUS-DNA INTEGRATION AND EXPRESSION OF AN ERB B-LIKE GENE IN HUMAN HEPATOCELLULAR-CARCINOMA

被引：29

作者：

ZHANG, XK

EGAN, JO

HUANG, DP

SUN, ZL

CHIEN, VKY

CHIU, JF

机构：

[1] Department of Biochemistry, College Of Medicine University of Vermont, Burlington

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)92391-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Southern blot studies on Hepatitis B Virus (HBV) DNA integration in 13 human hepatocellular carcinomas (HCCs) patients revealed the presence of several distinct HBV integration sites in different human liver disease patients. In one HCC patient the DNA fragment containing the HBV integration also hybridized to an erb B probe. The erb B/HBV co-migrating DNA fragment was cloned and sequenced, and showed that HBV DNA is integrated next to a cellular DNA fragment which is homologous to the tyrosine protein kinase domain of the human epidermal growth factor receptor gene and other cell surface receptor genes. The virus-integrated cellular DNA sequence is expressed in this HCC patient, suggesting a possible role for this gene in hepatocarcinogenesis. © 1992.

引用

收藏

页码：344 / 351

页数：8

相关论文

共 33 条

[21] DELETION IN CHROMOSOME-11P ASSOCIATED WITH A HEPATITIS-B INTEGRATION SITE IN HEPATOCELLULAR-CARCINOMA [J].

ROGLER, CE ;

SHERMAN, M ;

SU, CY ;

SHAFRITZ, DA ;

SUMMERS, J ;

SHOWS, TB ;

HENDERSON, A ;

KEW, M .

SCIENCE, 1985, 230 (4723) :319-322

[22] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].

SANGER, F ;

NICKLEN, S ;

COULSON, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467

[23] A V-ERBB-RELATED PROTOONCOGENE, C-ERBB-2, IS DISTINCT FROM THE C-ERBB-1/EPIDERMAL GROWTH FACTOR-RECEPTOR GENE AND IS AMPLIFIED IN A HUMAN SALIVARY-GLAND ADENOCARCINOMA [J].

SEMBA, K ;

KAMATA, N ;

TOYOSHIMA, K ;

YAMAMOTO, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6497-6501

[24]

SLAGLE BL, 1991, CANCER RES, V51, P49

[25] THE HEPATITIS-B VIRUS [J].

TIOLLAIS, P ;

POURCEL, C ;

DEJEAN, A .

NATURE, 1985, 317 (6037) :489-495

[26] CHROMOSOMAL TRANSLOCATION AND INVERTED DUPLICATION ASSOCIATED WITH INTEGRATED HEPATITIS-B VIRUS IN HEPATOCELLULAR CARCINOMAS [J].

TOKINO, T ;

FUKUSHIGE, S ;

NAKAMURA, T ;

NAGAYA, T ;

MUROTSU, T ;

SHIGA, K ;

AOKI, N ;

MATSUBARA, K .

JOURNAL OF VIROLOGY, 1987, 61 (12) :3848-3854

[27] HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR CDNA SEQUENCE AND ABERRANT EXPRESSION OF THE AMPLIFIED GENE IN A431 EPIDERMOID CARCINOMA-CELLS [J].

ULLRICH, A ;

COUSSENS, L ;

HAYFLICK, JS ;

DULL, TJ ;

GRAY, A ;

TAM, AW ;

LEE, J ;

YARDEN, Y ;

LIBERMANN, TA ;

SCHLESSINGER, J ;

DOWNWARD, J ;

MAYES, ELV ;

WHITTLE, N ;

WATERFIELD, MD ;

SEEBURG, PH .

NATURE, 1984, 309 (5967) :418-425

[28] MULTIPLE REARRANGEMENTS AND ACTIVATED EXPRESSION OF C-MYC INDUCED BY WOODCHUCK HEPATITIS-VIRUS INTEGRATION IN A PRIMARY LIVER-TUMOR [J].

WEI, Y ;

PONZETTO, A ;

TIOLLAIS, P ;

BUENDIA, MA .

RESEARCH IN VIROLOGY, 1992, 143 (02) :89-96

[29] THE ERBB GENE OF AVIAN ERYTHROBLASTOSIS VIRUS IS A MEMBER OF THE SRC GENE FAMILY [J].

YAMAMOTO, T ;

NISHIDA, T ;

MIYAJIMA, N ;

KAWAI, S ;

OOI, T ;

TOYOSHIMA, K .

CELL, 1983, 35 (01) :71-78

[30] SIMILARITY OF PROTEIN ENCODED BY THE HUMAN C-ERB-B-2 GENE TO EPIDERMAL GROWTH-FACTOR RECEPTOR [J].

YAMAMOTO, T ;

IKAWA, S ;

AKIYAMA, T ;

SEMBA, K ;

NOMURA, N ;

MIYAJIMA, N ;

SAITO, T ;

TOYOSHIMA, K .

NATURE, 1986, 319 (6050) :230-234

← 1 2 3 4 →