PLASMA AND TISSUE CONCENTRATIONS OF ALPHA-TOCOPHEROL DURING VITAMIN-E DEPLETION IN SHEEP

被引：25

作者：

FRY, JM ^{[1
]}

SMITH, GM ^{[1
]}

MCGRATH, MC ^{[1
]}

SPEIJERS, EJ ^{[1
]}

ALLEN, JG ^{[1
]}

机构：

[1] WESTERN AUSTRALIA DEPT AGR,DIV PLANT IND,S PERTH,WA 6151,AUSTRALIA

来源：

BRITISH JOURNAL OF NUTRITION | 1993年 / 69卷 / 01期

关键词：

ALPHA-TOCOPHEROL; VITAMIN-E; NUTRITIONAL MYOPATHY; SHEEP;

D O I：

10.1079/BJN19930024

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

To determine the relationship between plasma and tissue alpha-tocopherol concentrations during vitamin E depletion, weaned lambs were placed on a vitamin F-deficient diet for 0, 1, 2, 4, 8 and 12 weeks. Alpha-Tocopherol was measured in plasma, erythrocytes, liver, adrenal, adipose tissue, three different skeletal muscles and heart muscle. The alpha-tocopherol concentration in plasma fell at the same rate as the alpha-tocopherol concentration in skeletal muscles, heart muscle, adrenal and adipose tissue. The alpha-tocopherol concentration in liver and erythrocytes fell at a faster rate than that of plasma and all muscle tissues. There were significant correlations between alpha-tocopherol concentration in plasma and alpha-tocopherol concentrations in all the tissues measured. Different skeletal muscles had significantly different concentrations of alpha-tocopherol which may relate to their differing susceptibility to nutritional myopathy. The increase in malondialdehyde in oxidatively-stressed muscle tissue and the correlation with alpha-tocopherol concentration in most muscle tissues indicated that the muscles had reduced antioxidant capacity in vitro as a result of vitamin E depletion. It was concluded that during vitamin E depletion in sheep alpha-tocopherol concentration in plasma was a good index of vitamin E status under the experimental conditions employed.

引用

页码：225 / 232

页数：8

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