ANTIBIOTICS FROM BASIDIOMYCETES .37. NEW INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS FROM CULTURES OF XERULA-MELANOTRICHA DORFELT

被引：81

作者：

KUHNT, D

ANKE, T

BESL, H

BROSS, M

HERRMANN, R

MOCEK, U

STEFFAN, B

STEGLICH, W

机构：

[1] UNIV KAISERSLAUTERN,LEHRBEREICH BIOTECHNOL,PAUL EHRLICH STR 23,W-6750 KAISERSLAUTERN,GERMANY

[2] UNIV REGENSBURG,INST BOT,W-8400 REGENSBURG,GERMANY

[3] UNIV BONN,INST ORGAN CHEM,W-5300 BONN 1,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 11期

关键词：

D O I：

10.7164/antibiotics.43.1413

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of C-14- acetate into cholesterol in HeLa cells while the incorporation of C-14-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.

引用

页码：1413 / 1420

页数：8

共 19 条

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HERRMANN R, 1980, THESIS U BONN

[12] GROWTH AND MAINTENANCE OF HELA-CELLS IN SERUM-FREE MEDIUM SUPPLEMENTED WITH HORMONES [J].