ESTIMATION OF CHROMIUM-51 ETHYLENE DIAMINE TETRAACETIC ACID PLASMA-CLEARANCE - A COMPARATIVE-ASSESSMENT OF SIMPLIFIED TECHNIQUES

被引:56
作者
PICCIOTTO, G [1 ]
CACACE, G [1 ]
CESANA, P [1 ]
MOSSO, R [1 ]
ROPOLO, R [1 ]
DEFILIPPI, PG [1 ]
机构
[1] MOLINETTE MAURIZIANO HOSP, SERV FIS SANITARIA, I-10126 TURIN, ITALY
来源
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1992年 / 19卷 / 01期
关键词
CHROMIUM-51 ETHYLENE DIAMINE TETRAACETIC ACID (CR-51-EDTA); GLOMERULAR FILTRATION RATE (GFR) TOTAL PLASMA CLEARANCE; KIDNEY FUNCTION;
D O I
10.1007/BF00178305
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Chromium-51 ethylene diamine tetra-acetic acid (Cr-51-EDTA) total plasma clearance was evaluated using a multi-sample method (i.c. 12 blood samples) as the reference compared with several simplified methods which necessitated only one or few blood samples. The following 5 methods were evaluated: terminal slope-intercept method with 3 blood samples, simplified method of Brochner-Mortensen and 3 single-sample methods (Constable, Christensen and Groth, Tauxc). Linear regression analysis was performed. Standard error of estimate, bias and imprecision of different methods were evaluated. For Cr-51-EDTA total plasma clearance greater than 30 ml.min-1, the results which most approximated the reference source were obtained by the Christensen and Groth method at a sampling time of 300 min (inaccuracy of 4.9%). For clearances between 10 and 30 ml.min-1, single-sample methods failed to give reliable results. Terminal slope-intercept and Brochner-Mortensen methods were better, with inaccuracies of 17.7% and 16.9%, respectively. Although sampling times at 180, 240 and 300 min are time-consuming for patients, Cr-51-EDTA total plasma clearance can be accurately calculated for values greater than 10 ml-min-1 using the Brochner-Mortensen method. In patients with clearance greater than 30 ml.min-1, single-sample techniques provide a good alternative to the multi-sample method; the choice of the method to be used depends on the degree of accuracy required.
引用
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页码:30 / 35
页数:6
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