BOVINE VIRUS DIARRHEA VIRUS INDUCES INVITRO A PROLIFERATIVE RESPONSE OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM CATTLE IMMUNIZED BY INFECTION

被引：16

作者：

LARSSON, B ^{[1
]}

FOSSUM, C ^{[1
]}

机构：

[1] SWEDISH UNIV AGR SCI, DEPT VET MICROBIOL, IMMUNOL SECT, S-75007 UPPSALA, SWEDEN

来源：

VETERINARY MICROBIOLOGY | 1992年 / 31卷 / 04期

关键词：

D O I：

10.1016/0378-1135(92)90124-C

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of bovine peripheral blood mononuclear cells (PBMC) to mount a proliferative response to bovine virus diarrhoea virus (BVDV) in vitro was examined. After culturing PBMC in the presence of a non-cytopathic strain of BVDV for 6 days, the magnitude of PBMC proliferation was measured as incorporation of radiolabelled thymidine, present during the last 18 h. Live, but not heat-inactivated, BVDV evoked a proliferative response of PBMC obtained from cattle seropositive to the virus. However, PBMC from seronegative or persistently BVDV-infected animals were not stimulated by BVDV. The presence of live BVDV did not alter the proliferative response of PBMC to stimulation with concanavalin A.

引用

页码：317 / 325

页数：9

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