NEW SYNTHESES OF BENZOPORPHYRIN DERIVATIVES AND ANALOGS FOR USE IN PHOTODYNAMIC THERAPY

被引：14

作者：

MEUNIER, I

PANDEY, RK

WALKER, MM

SENGE, MO

DOUGHERTY, TJ

SMITH, KM

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

[2] ROSWELL PK CANC INST,DEPT RADIAT MED,BUFFALO,NY 14263

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80433-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study.

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收藏

页码：1575 / 1580

页数：6

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