BURST FIRING OF RAT SEPTAL NEURONS INDUCED BY 1S,3R-ACPD REQUIRES INFLUX OF EXTRACELLULAR CALCIUM

被引：14

作者：

FANG, Z ^{[1
]}

GALLAGHER, JP ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL & TOXICOL,GALVESTON,TX 77550

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 211卷 / 02期

关键词：

METABOTROPIC GLUTAMATE RECEPTOR; CA-2+ (EXTERNAL); 1S,3R-ACPD (1S,3R-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID);

D O I：

10.1016/0014-2999(92)90542-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have demonstrated that burst firing in rat dorsolateral septal nucleus neurons is a specific response following activation of metabotropic glutamate receptors. Now we report that the burst firing induced by 1S,3R-ACPD (1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid), a selective agonist, is blocked by inorganic calcium channel blockers. Our data suggest that influx of external calcium is required for this metabotropic glutamate response. Intracellular second messenger pathways coupled to the metabotropic glutamate receptor may be more complex than releasing calcium from IP3-sensitive internal stores as is currently hypothesized.

引用

页码：281 / 282

页数：2

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