LEAD-CONTAMINATED SOIL ABATEMENT AND URBAN CHILDRENS BLOOD LEAD LEVELS

被引:116
作者
WEITZMAN, M
ASCHENGRAU, A
BELLINGER, D
JONES, R
HAMLIN, JS
BEISER, A
机构
[1] UNIV ROCHESTER,SCH MED & DENT,DEPT PEDIAT,ROCHESTER,NY 14642
[2] BOSTON UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL & BIOSTAT,BOSTON,MA 02215
[3] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115
[4] DEPT PUBL HLTH,CLEVELAND,OH
[5] CEDARS SINAI MED CTR,DEPT PEDIAT,LOS ANGELES,CA 90048
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1993年 / 269卷 / 13期
关键词
D O I
10.1001/jama.269.13.1647
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective.-To test the hypothesis that a reduction of 1 000 ppm or more of lead in soil accessible to children would result in a decrease of at least 0.14 mumol/L (3 mug/dL) in blood lead levels. Setting.-Urban neighborhoods with a high incidence of childhood lead poisoning and high soil lead levels. Design.-Randomized controlled trial of the effects of lead-contaminated soil abatement on blood lead levels of children followed up for approximately 1 year after the intervention. Patients.-A total of 152 children less than 4 years of age with venous blood lead levels of 0.34 to 1.16 mumol/L (7 to 24 mug/dL). Children were largely poor and had a mean age at baseline of 32 months, a mean blood lead level of 0.60 mumol/L (12.5 mug/dL), and a median surface soil lead level of 2075 ppm. Interventions.-Children were randomized to one of three groups: the study group, whose homes received soil and interior dust abatement and loose paint removal; comparison group A, whose homes received interior dust abatement and loose paint removal; and comparison group B, whose homes received only interior loose paint removal. Main Outcome Measures.-Change in children's blood lead levels from preabatement levels to levels approximately 6 and 11 months after abatement. Results.-The mean decline in blood lead level between preabatement and 11 months after abatement was 0.12 mumol/L (2.44 mug/dL) in the study group (P=.001), 0.04 mumol/L (0.91 mug/dL) in group A (P=.04), and 0.02 mumol/L (0.52 mug/mL) in group B (P=.31). The mean blood lead level of the study group declined 0.07 mumol/L (1.53 mug/dL) more than that of group A (95% confidence interval [CI], -0.14 to -0.01 mumol/L [-2.87 to -0.19 mug/dL]) and 0.09 mumol/L (1.92 mug/dL) more than group B (95% CI, -0.16 to -0.03 mumol/L [-3.28 to -0.56 mug/dL]). When adjusted for preabatement lead level, the 11-month mean blood lead level was 0.06 mumol/L (1.28 mug/dL) lower in the study group as compared with group A (P=.02) and 0.07 mumol/L (1.49 mug/dL) lower than in group B (P=.01). The magnitude of th decline independently associated with soil abatement ranged from 0.04 to 0.08 mumol/L (0.8 to 1.6 mug/dL) when the impact of potential confounders, such as water, dust, and paint lead levels, children's mouthing behaviors, and other characteristics, was controlled for. Conclusions.-These results demonstrate that lead-contaminated soil contributes to the lead burden of urban children and that abatement of lead-contaminated soil around homes results in a modest decline in blood lead levels. The magnitude of reduction in blood lead level observed, however, suggests that lead-contaminated soil abatement is not likely to be a useful clinical intervention for the majority of urban children in the United States with low-level lead exposure.
引用
收藏
页码:1647 / 1654
页数:8
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