IMMUNOHISTOCHEMICAL STUDY OF A CASE WITH PROGRESSIVE SUPRANUCLEAR PALSY WITHOUT OPHTHALMOPLEGIA

被引：16

作者：

KIDA, E ^{[1
]}

BARCIKOWSKA, M ^{[1
]}

NIEMCZEWSKA, M ^{[1
]}

机构：

[1] WARSAW ACAD MED & HOSP,DEPT NEUROL 2,WARSAW,POLAND

来源：

ACTA NEUROPATHOLOGICA | 1992年 / 83卷 / 03期

关键词：

PROGRESSIVE SUPRANUCLEAR PALSY; NEUROFIBRILLARY TANGLES; MICROGLIA; IMMUNOHISTOCHEMISTRY; MODIFIED TAU PROTEIN;

D O I：

10.1007/BF00296797

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A case of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome; PSP) with parkinsonism and absence of gaze palsy or mental changes is reported. Neuropathological examination, apart from typical changes, showed, lack of midbrain tegmentum demyelination, marked loss of Purkinje cells and presence of hyalin-like bodies in individual neurons of the substantial nigra. Immunostaining against tau-l protein revealed the prevalence of a diffuse reaction in locus coeruleus neurons; reflecting either different ability of these cells to accumulate straight filaments, or a various time sequence of neurofibrillary tangles formation. Ferritin immunohistochemistry demonstrated widespread microglial cell proliferation, confirming further the generalized character of CNS pathology in PSP.

引用

页码：328 / 332

页数：5

共 31 条

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