MONOCLONAL ANTIBODY;
HUMAN CYTOMEGALOVIRUS;
HCMV;
HCMV-SPECIFIC;
D O I:
10.1016/0166-3542(92)90046-8
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
A combination of HCMV-specific monoclonal antibodies (MAbs) reactive with glycoproteins in gcI complexes which exhibit synergistic antiviral activity in vitro is described. MAbs directed against different structural and biological properties of HCMV have been selected to increase the antiviral activity against all possible strains. and to reduce the likelihood that resistant strains will emerge with prolonged exposure. Furthermore, in vitro analysis demonstrates that certain of the MAbs in the combination augment the virus-neutralizing activity of other component antibodies, thereby decreasing the amount of total antibody protein required to inhibit HCMV infection. Certain MAbs have been selected to inactivate extracellular virus during the early phase of HCMV infection, whereas others have been selected to prevent its spread once cells have been infected. These data suggest that a MAb cocktail may be useful for prophylaxis and treatment of patients at risk of life-threatening HCMV infections.
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页码:115 / 131
页数:17
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[51]
WENTHWOR.BB, 1970, P SOC EXP BIOL MED, V135, P253, DOI 10.3181/00379727-135-35031
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
WINSTON, DJ
;
HO, WG
论文数: 0引用数: 0
h-index: 0
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UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
HO, WG
;
LIN, CH
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
LIN, CH
;
BARTONI, K
论文数: 0引用数: 0
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UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
BARTONI, K
;
BUDINGER, MD
论文数: 0引用数: 0
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UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
BUDINGER, MD
;
GALE, RP
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
GALE, RP
;
CHAMPLIN, RE
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机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
WINSTON, DJ
;
HO, WG
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
HO, WG
;
LIN, CH
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
LIN, CH
;
BARTONI, K
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
BARTONI, K
;
BUDINGER, MD
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
BUDINGER, MD
;
GALE, RP
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA
GALE, RP
;
CHAMPLIN, RE
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USAUNIV CALIF LOS ANGELES, CTR HLTH SCI, TRANSPLANTAT BIOL PROGRAM, LOS ANGELES, CA 90024 USA