AUTOIMMUNIZATION AGAINST THE NEUTROPHIL-SPECIFIC NA1 ANTIGEN IS ASSOCIATED WITH HLA-DR2

被引：30

作者：

BUX, J ^{[1
]}

MUELLERECKHARDT, G ^{[1
]}

MUELLERECKHARDT, C ^{[1
]}

机构：

[1] UNIV GIESSEN, INST CLIN IMMUNOL & TRANSFUS MED, LANGHANSSTR 7, W-6300 GIESSEN, GERMANY

来源：

HUMAN IMMUNOLOGY | 1991年 / 30卷 / 01期

关键词：

D O I：

10.1016/0198-8859(91)90065-H

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A significant association of autoimmune neutropenia (AIN) in infants due to NA1-specific autoantibodies and HLA-DR2 is reported. Nineteen of 26 infants presenting with AIN and NA1 autoantibodies possessed the DR2 antigen, while only one out of six children with AIN, but non-NA1-specific autoantibodies, was DR2 positive. Furthermore, one adult patient with primary biliary cirrhosis and periods of neutropenia due to NA1 autoantibodies also carried the DR2 antigen. All DR2-negative patients were positive for DRw6. These findings indicate that a close relationship exists between autoimmunization against the NA1 antigen and HLA-DR2 and possibly also DRw6.

引用

页码：18 / 21

页数：4