VITAMIN-E IN THE TREATMENT OF CHEMOTHERAPY-INDUCED MUCOSITIS

被引：104

作者：

WADLEIGH, RG ^{[1
]}

REDMAN, RS ^{[1
]}

GRAHAM, ML ^{[1
]}

KRASNOW, SH ^{[1
]}

ANDERSON, A ^{[1
]}

COHEN, MH ^{[1
]}

机构：

[1] VET ADM MED CTR,DENT SERV,WASHINGTON,DC 20422

来源：

AMERICAN JOURNAL OF MEDICINE | 1992年 / 92卷 / 05期

关键词：

D O I：

10.1016/0002-9343(92)90744-V

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PURPOSE: To determine the efficacy of vitamin E in the treatment of chemotherapy-induced mucositis in patients with malignancy. PATIENTS AND METHODS: A randomized, double-blind, placebo-controlled study was performed to evaluate the efficacy of topical vitamin E in the treatment of oral mucositis in patients receiving chemotherapy for various types of malignancy. A total of 18 patients, 17 of whom had solid tumors and one with acute leukemia, were included in this study. Lesions were observed daily prior to and 5 days after topical application of either vitamin E or placebo oil. RESULTS: Six of nine patients receiving vitamin E had complete resolution of their oral lesions. In eight of nine patients who received placebo, complete resolution of their oral lesions was not observed. This difference is statistically significant (p = 0.025 by Fisher's exact test). No toxicity was observed in this study. CONCLUSION: These results suggest that vitamin E may be an effective therapy in patients with chemotherapy-induced mucositis.

引用

页码：481 / 484

页数：4