DETERMINATION OF 6-(2'-CHLOROPHENYL)-4-HYDROXY-4H-IMIDAZO[1,5-ALPHA][1,4]BENZODIAZEPINE-3-CARBOXAMIDE, A MIXED AGONIST ANTAGONIST ANXIOLYTIC AGENT, IN HUMAN-PLASMA AND URINE BY GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL-IONIZATION MASS-SPECTROMETRY

被引：6

作者：

RUBIO, F ^{[1
]}

CHEN, S ^{[1
]}

CREWS, T ^{[1
]}

DEGRAZIA, F ^{[1
]}

GARLAND, WA ^{[1
]}

BARBALAS, M ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,DEPT DRUG METAB,NUTLEY,NJ 07110

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1987年 / 421卷 / 02期

关键词：

D O I：

10.1016/0378-4347(87)80408-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

引用

页码：281 / 289

页数：9

共 6 条

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[2] DETERMINATION OF CLONAZEPAM IN HUMAN-PLASMA BY GAS CHROMATOGRAPHY NEGATIVE ION CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

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[3] DETERMINATION OF THE AGONIST ANTAGONIST ANXIOLYTIC AGENT 6-(2-CHLOROPHENYL)-4-HYDROXY-4H-IMIDAZO[1,5-ALPHA]-[1,4]BENZODIAZEPINE-3-CARBOXAMIDE AND ITS BENZOPHENONE CARBOXYLIC-ACID METABOLITE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

PUGLISI, CV ;

FERRARA, FJ ;

BEKERSKY, I .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 417 (02) :347-356

[4] DETERMINATION OF IMIDAZOBENZODIAZEPINE-3-CARBOXAMIDE, A NEW ANXIOLYTIC AGENT, IN HUMAN-PLASMA BY GAS-CHROMATOGRAPHY NEGATIVE CHEMICAL-IONIZATION MASS-SPECTROMETRY [J].

RUBIO, F ;

MIWA, BJ ;

GARLAND, WA .

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[5]

SEPINWALL J, 1986, Society for Neuroscience Abstracts, V12, P661

[6] A STANDARD APPROACH TO COMPILING CLINICAL PHARMACOKINETIC DATA [J].

SHEINER, LB ;

BENET, LZ ;

PAGLIARO, LA .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1981, 9 (01) :59-127

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