SYNTHESIS OF (+/-)-PHYLLANTHOCIN VIA A METAL-CATALYZED CYCLOREDUCTION

被引：45

作者：

TROST, BM

EDSTROM, ED

机构：

[1] Department of Chemistry, Stanford University, Stanford, California

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 05期

关键词：

D O I：

10.1002/anie.199005201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cycloreduction of the enyne 2 to a precursor of the title compound 1 is the key step in a total synthesis of 1. The reaction occurs under Pd catalysis with a yield of 86%. This is a case in which the Alder ene reaction proved unsuccessful. Compound 1 is the aglycone of the clinically interesting antitumor agent phyllanthoside (TIPS = iPr3Si). (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

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页码：520 / 522

页数：3

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