MICROBIAL ASYMMETRIC REDUCTION OF ETHYL 4-CHLORO-3-OXOBUTANOATE TO OPTICALLY-ACTIVE ETHYL 4-CHLORO-3-HYDROXYBUTANOATE

被引:36
作者
SHIMIZU, S [1 ]
KATAOKA, M [1 ]
MORISHITA, A [1 ]
KATOH, M [1 ]
MORIKAWA, T [1 ]
MIYOSHI, T [1 ]
YAMADA, H [1 ]
机构
[1] DENKI KAGAKU KOGYO,RES CTR,DEPT BIOCHEM,TOKYO 194,JAPAN
关键词
D O I
10.1007/BF01030758
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate through the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate with the NADPH-dependent aldehyde reductase of Sporobolomyces salmonicolor AKU 4429 is described. Under preparative scale reaction conditions with the acetone-fractionated aldehyde reductase, the amount of ethyl-4-chloro-3-hydroxybutanoate reached 33.1 mg/ml (85%ee; molar yield, 74.0%). Furthermore, conversion to ethyl (S)-4-chloro-3-hydroxybutanoate occurred on incubation with washed cells of Trichosporon cutaneum AKU 4864 as the catalyst. © 1990 Science and Technology Letters.
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页码:593 / 596
页数:4
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