LIPID MEDIATORS AND PROTEIN-KINASE-C ACTIVATION FOR THE INTRACELLULAR SIGNALING NETWORK

被引：140

作者：

NAKAMURA, S ^{[1
]}

NISHIZUKA, Y ^{[1
]}

机构：

[1] KOBE UNIV, BIOSIGNAL RES CTR, NADA KU, KOBE 657, JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1994年 / 115卷 / 06期

关键词：

DIACYLGLYCEROL; PHOSPHOLIPASE A(2); PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN KINASE C;

D O I：

10.1093/oxfordjournals.jbchem.a124451

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon stimulation of a cell surface receptor, a membrane phospholipid degradation cascade is often induced through the activation of several phospholipases, yielding various lipid metabolites such as diacylglycerol, free fatty acids, lysophospholipids, and phosphatidic acid. Several isoforms of protein kinase C are each activated distinctly by various combinations of the lipid metabolites, presumably in different subcellular compartments. The pivotal role of this enzyme family in the intracellular signaling network is beginning to emerge.

引用

页码：1029 / 1034

页数：6

共 67 条

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