IN-VITRO T-CELL FUNCTION, DELAYED-TYPE HYPERSENSITIVITY SKIN TESTING, AND CD4(+) T-CELL SUBSET PHENOTYPING INDEPENDENTLY PREDICT SURVIVAL-TIME IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4(+) cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toroid, and influenza A virus. The T cell functional assay predicted survival time (P < .001) and time for progression to AIDS (P = .014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P < .001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P = .008), the absolute number of CD4(+) T cells (P = .001), the percentage of CD4(+)CD29(+) cells (P = .06), and the number of reactive skin tests (P < .001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-l-infected patients independent of CD4(+) cell count.