THE EFFECTS OF DEPRENYL ON METHAMPHETAMINE-INDUCED DOPAMINE DEPLETIONS

被引：10

作者：

JOHNSON, SK ^{[1
]}

MEDINA, D ^{[1
]}

WAGNER, GC ^{[1
]}

机构：

[1] RUTGERS STATE UNIV, DEPT PSYCHOL, NEW BRUNSWICK, NJ 08903 USA

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1992年 / 89卷 / 1-2期

关键词：

DOPAMINE; DEPRENYL; METHAMPHETAMINE; PARKINSONS DISEASE;

D O I：

10.1007/BF01245358

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of deprenyl on methamphetamine-induced dopamine depletions were studied in mice. Four SC injections of 12.5 mg/kg of methamphetamine at two-hour intervals caused substantial (72-82%) and long-lasting depletions of striatal dopamine. Pretreatment with either 25 or 40 mg/kg of deprenyl did not significantly alter the magnitude of this depletion. These results indicate that, unlike what is observed following MPTP, there is no protection afforded dopaminergic cells by deprenyl pretreatment in the methamphetamine model of parkinsonism.

引用

页码：123 / 127

页数：5

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