ESTIMATION OF THE LC50, A REVIEW

被引:33
作者
HOEKSTRA, JA
机构
[1] Centre for Mathematical Methods, National Institute of Public Health and Environmental Protection, Bilthoven, 3720 BA
关键词
BACKGROUND MORTALITY; BIOASSAY; LC50; ESTIMATOR; LIKELIHOOD METHODS; LOGIT ANALYSIS; MOVING AVERAGE; PROBIT ANALYSIS; SPEARMAN-KARBER ESTIMATOR; TOXICITY TEST; TRIMMING;
D O I
10.1002/env.3770020203
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In this paper methods to estimate the median lethal concentration (LC50) are reviewed. Estimation from data sets with limited occurrence of partial response (> 0%, < 100%) receives particular attention.
引用
收藏
页码:139 / 152
页数:14
相关论文
共 43 条
[11]  
Finney D.J., The estimation of the mean of a normal tolerance distribution, Sankhya, 10, pp. 341-360, (1950)
[12]  
Finney D.J., The estimation of the ED50 for a logistic response curve, Sankhya, 12, pp. 121-136, (1953)
[13]  
Finney D.J., Probit Analysis, (1971)
[14]  
Finney D.J., Statistical Methods in Biological Assay, (1978)
[15]  
Finney D.J., The median lethal dose and its estimation, Archives of Toxicology, 56, pp. 215-218, (1985)
[16]  
Goedhart P.W., (1986)
[17]  
Govindarajulu Z., Statistical Techniques in Bioassay, (1988)
[18]  
Hamilton M.A., Robust estimates of the ED50, Journal of the American Statistical Association, 74, pp. 344-354, (1979)
[19]  
Hamilton M.A., Inference about the ED50 using the trimmed Spearman‐Kärber procedure — a Monte Carlo investigation, Communications in Statistics, 9 B, pp. 235-254, (1980)
[20]  
Hamilton M.A., Russo P.C., Thurston R.V., Trimmed Spearman‐Kärber method for estimating median lethal concentrations in toxicity bioassays, Environmental Science and Technology, 11, pp. 714-719, (1977)