PHOSPHOCITRATE PREVENTS DISEASE PROGRESSION IN MURINE PROGRESSIVE ANKYLOSIS

被引：38

作者：

KRUG, HE

MAHOWALD, ML

HALVERSON, PB

SALLIS, JD

CHEUNG, HS

机构：

[1] MED COLL WISCONSIN,DEPT MED,DIV RHEUMATOL,MILWAUKEE,WI 53226

[2] UNIV TASMANIA,DEPT BIOCHEM,HOBART,TAS 7001,AUSTRALIA

[3] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455

[4] MINNEAPOLIS VET AFFAIRS MED CTR,DEPT MED,MINNEAPOLIS,MN

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 11期

关键词：

D O I：

10.1002/art.1780361116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. Results. Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice. Conclusion. PC appears to inhibit disease progression in murine progressive ankylosis.

引用

页码：1603 / 1611

页数：9

共 15 条

[11] SYNTHESIS AND CHARACTERIZATION OF PHOSPHOCITRIC ACID, A POTENT INHIBITOR OF HYDROXYLAPATITE CRYSTAL-GROWTH [J].