CADMIUM, ZINC AND COPPER IN HORSE KIDNEY METALLOTHIONEIN

被引：40

作者：

NORDBERG, M ^{[1
]}

ELINDER, CG ^{[1
]}

RAHNSTER, B ^{[1
]}

机构：

[1] NATL SWEDISH ENVIRONM PROTECT BOARD, STOCKHOLM, SWEDEN

来源：

ENVIRONMENTAL RESEARCH | 1979年 / 20卷 / 02期

关键词：

D O I：

10.1016/0013-9351(79)90010-0

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Cadium, zinc, and copper were determined in kidney cortex samples and in protein fractions obtained from 20 normal Swedish horses. Cadmium concentrations in kidneys ranged from 0.01 to 1.46 mmole/kg. Zinc concentrations in kidneys increased with increasing cadmium concentrations. At low concentrations of cadmium the increase of zinc was almost equimolar with the increase in cadmium, but at higher concentrations of cadmium the increase of zinc was less pronounced. Copper concentrations ranged from 0.07 to 0.22 mmole Cu/kg and were not related to the cadmium concentration. The increase of zinc in kidney cortex took place in the metallothionein (MT) fractions, where also almost all cadmium was recovered. The molar ratio of zinc and cadmium in MT was close to one at low concentrations (below 0.1 mmole/kg) of cadmium but the ratio decreased with increasing cadmium concentrations in the kidney. This change in molar ratio of zinc and cadmium in MT explains the leveling off in zinc increase at cadmium concentrations in kidney exceeding 0.6 mmole/kg. © 1979.

引用

页码：341 / 350

页数：10

共 32 条

[11]

ELINDER CG, 1978, TRACE ELEMENT METABO, V3, P569

[12]

FRIBERG L, 1974, CADMIUM ENV

[13]

KAEGI JH, 1961, J BIOL CHEM, V236, P2435

[14]

Kagi J.H.R., 1979, METALLOTHIONEIN

[15]

KAGI JHR, 1960, J BIOL CHEM, V235, P3460

[16] AMINO-ACID-SEQUENCE OF EQUINE RENAL METALLOTHIONEIN-1B [J].

KOJIMA, Y ;

BERGER, C ;

VALLEE, BL ;

KAGI, JHR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (10) :3413-3417

[17] METALLOTHIONEIN [J].

KOJIMA, Y ;

KAGI, JHR .

TRENDS IN BIOCHEMICAL SCIENCES, 1978, 3 (04) :90-93

[18] RELATIONSHIP OF METALLOTHIONEIN TO TOXICITY OF CADMIUM AFTER PROLONGED ORAL-ADMINISTRATION TO RATS [J].

KOTSONIS, FN ;

KLAASSEN, CD .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1978, 46 (01) :39-54

[19] A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX [J].

MARGOSHES, M ;

VALLEE, BL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (17) :4813-4814

[20] SEPARATION OF 2 FORMS OF RABBIT METALLOTHIONEIN BY ISOELECTRIC FOCUSING [J].

NORDBERG, GF ;

NORDBERG, M ;

VESTERBERG, O ;

PISCATOR, M .

BIOCHEMICAL JOURNAL, 1972, 126 (03) :491-+

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