OLIGONUCLEOTIDE DOT-BLOT ANALYSIS OF HLA-DQ-BETA ALLELES ASSOCIATED WITH MULTIPLE-SCLEROSIS

被引：9

作者：

SINHA, AA

BELL, RB

STEINMAN, L

MCDEVITT, HO

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT NEUROL,STANFORD,CA 94305

[2] STANFORD UNIV,MED CTR,SCH MED,DEPT PEDIAT,STANFORD,CA 94305

[3] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305

[4] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,STANFORD,CA 94305

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 32卷 / 01期

关键词：

HLA-DQ-BETA ALLELE; HISTOCOMPATIBILITY ANTIGEN; MULTIPLE SCLEROSIS; GENETIC SUSCEPTIBILITY;

D O I：

10.1016/0165-5728(91)90072-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oligonucleotide probes were used to investigate the role of DQ-beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ-beta-1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.

引用

页码：61 / 65

页数：5