LONG-TERM POTENTIATION OF APLYSIA SENSORIMOTOR SYNAPSES IN CELL-CULTURE - REGULATION BY POSTSYNAPTIC VOLTAGE

被引:75
作者
LIN, XY
GLANZMAN, DL
机构
[1] Department of Physiological Science, University of California, Los Angeles, CA 90024-1568
关键词
D O I
10.1098/rspb.1994.0016
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Long-term potentiation (LTP) has been proposed as a cellular mechanism for associative learning in vertebrates. Induction of one type of LTP - observed at synapses in the CA1 region of the mammalian hippocampus - is regulated by the voltage of the postsynaptic cell. To date, a similar form of LTP has not been demonstrated for any invertebrate synapse. We now report that high-frequency stimulation can induce LTP of sensorimotor synapses of the marine mollusc Aplysia in cell culture. Moreover, induction of this form of LTP appears to involve a voltage-dependent postsynaptic mechanism because pairing tetanic stimulation of the presynaptic cell with strong hyperpolarization of the postsynaptic cell blocks the induction of LTP.
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页码:113 / 118
页数:6
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