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ENHANCEMENT OF ROTAVIRUS IMMUNOGENICITY BY MICROENCAPSULATION

被引：55
作者：
OFFIT, PA
KHOURY, CA
MOSER, CA
CLARK, HF
KIM, JE
SPEAKER, TJ
机构：
[1] WISTAR INST ANAT & BIOL, PHILADELPHIA, PA 19104 USA
[2] TEMPLE UNIV, SCH PHARM, PHILADELPHIA, PA 19140 USA
来源：
VIROLOGY | 1994年 / 203卷 / 01期
关键词：
D O I：
10.1006/viro.1994.1463
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
It was determined whether microencapsulation of rotavirus enhanced virus-specific immunity in mice. Combinations of several water-soluble anionic polymers and amines were tested for their capacity to form microcapsules which were stable in the presence of simulated gastric acid. Using the combinations of sodium alginate and spermine hydrochloride or sodium chondroitin sulfate and spermine hydrochloride we found that microcapsules (1) captured infectious rotavirus, (2) penetrated into the persisted in gut-associated lymphoid tissue (GALT) after oral inoculation, (3) delivered rotavirus antigen to GALT at levels greater than those detected after oral inoculation with free virus, and (4) enhanced the virus-specific humoral immune response after oral or parenteral immunization. (C) 1994 Academic Press, Inc.
引用
收藏
页码：134 / 143
页数：10
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