MOBILITY OF CURIUM-244 DIOXIDE IN THE BRONCHIALLY INTUBATED RAT

被引：14

作者：

STRADLING, GN

COOPER, JR

SMITH, H

HAM, SE

机构：

[1] National Radiological Protection Board, Harwell, Didcot, Oxfordshire, England

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1979年 / 36卷 / 01期

关键词：

D O I：

10.1080/09553007914550781

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mobility of curium dioxide in the rat after pulmonary intubation has been investigated by administering suspensions containing different particle size ranges of the oxide. A major factor influencing the movement of curium from lungs to blood is the formation of hydroxide or hydrous oxide particles about 0·001 μm in diameter. This process is sufficiently rapid for the lung clearance kinetics of the dioxide to resemble those of a soluble compound more closely than those of an insoluble one. Filtration of 0·001 μm particles through the kidneys results in considerably enhanced excretion of curium relative to administered curium citrate. It is concluded that current metabolic models, which assume that solubility in the lung is a prerequisite for transport in body fluids, do not adequately describe the behaviour of curium from the standpoint of radiological protection. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：19 / 32

页数：14

共 30 条

[11]

Langham WH, 1957, BR J RADIOL S, V7, P95

[12] SIALOGLYCOPROTEINS AND FILTRATION BARRIERS IN GLOMERULAR CAPILLARY WALL [J].

LATTA, H ;

JOHNSTON, WH ;

STANLEY, TM .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1975, 51 (03) :354-376

[13] EARLY EXCRETION, RETENTION AND DISTRIBUTION OF INJECTED CURIUM CITRATE IN BEAGLES [J].

LLOYD, RD ;

ATHERTON, DR ;

MAYS, CW ;

MCFARLAND, SS ;

WILLIAMS, JL .

HEALTH PHYSICS, 1974, 27 (01) :61-67

[14] RETENTION AND DISTRIBUTION OF CM-244 FOLLOWING INHALATION OF CM-244CL3 AND CM-244O1.73 BY BEAGLE DOGS [J].

MCCLELLAN, RO ;

BOYD, HA ;

THOMAS, RG ;

GALLEGOS, AF .

HEALTH PHYSICS, 1972, 22 (06) :877-+

[15] ON ROLE OF PARTICLE SIZE IN DISSOLUTION OF LUNG BURDENS [J].

MERCER, TT .

HEALTH PHYSICS, 1967, 13 (11) :1211-+

[16] PHASES AND TRANSFORMATIONS IN CURIUM-OXYGEN SYSTEM [J].

MOSLEY, WC .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1972, 34 (02) :539-&

[17]

PARKER HG, 1961, UCRL361 REP

[18]

PARSONT MA, 1972, HEALTH PHYS, V22, P143, DOI 10.1097/00004032-197202000-00003

[19]

POPPLEWELL DS, 1968, DIAGNOSIS TREATMENT, P45

[20]

RENKIN EM, 1973, RENAL PHYSL

← 1 2 3 →