Mutational analysis of protein stability

被引:47
作者
Matthews, Brian W. [1 ]
机构
[1] Univ Oregon, Dept Phys, Howard Hughes Med Inst, Eugene, OR 97403 USA
关键词
D O I
10.1016/0959-440X(91)90005-E
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ability to obtain mutant proteins almost at will, and to subject such variants to detailed structural, thermodynamic and theoretical analyses, is now making it possible to test, in a systematic way, the many longstanding beliefs and prejudices concerning the folding and stability of proteins.
引用
收藏
页码:17 / 21
页数:5
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