NO EFFECTS OF LOCAL SOMATOMEDIN-C ON BONE REPAIR - CONTINUOUS INFUSION IN RATS

被引：18

作者：

KIRKEBY, OJ

EKELAND, A

机构：

[1] UNIV OSLO,SOPHIES MINDE ORTOPED HOSP,OSLO 3,NORWAY

[2] UNIV OSLO,INST SURG RES,OSLO 3,NORWAY

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1992年 / 63卷 / 04期

关键词：

D O I：

10.3109/17453679209154765

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We studied the effect of continuous local application of human recombinant somatomedin C (110-mu-g/100 g/day) on bone repair in a rat femoral osteotomy model. The mechanical strength and various metabolic variables were evaluated four weeks postoperatively. We did not find any effect in the treatment group as compared to controls on torsional strength, deformation, or stiffness. Radiographic healing was similar in both groups. Nor was there any difference in callus weight, callus vascularization, or mineralization. Our results suggest that local administration of this dose of somatomedin C does not promote the early phase of diaphyseal repair in long bones.

引用

页码：447 / 450

页数：4

共 15 条

[11] LOCAL INJECTIONS OF HUMAN OR RAT GROWTH-HORMONE OR OF PURIFIED HUMAN SOMATOMEDIN-C STIMULATE UNILATERAL TIBIAL EPIPHYSEAL GROWTH IN HYPOPHYSECTOMIZED RATS [J].